[Immunostimulating and antitumor action of psychotropic preparations of the sydnonimine series]

Farmakol Toksikol. 1980 May-Jun;43(3):349-52.
[Article in Russian]

Abstract

In healthy animals and in those with different experimental tumours, the psychostimulant drug sydnophen activates the immune reactions: increases the number of RFC, the intensity of delayed hypersensitivity, blast transformation of lymphocytes, and the QD coefficient. This activation is attended by a slight inhibition of transplanted tumours. The psychostimulant sydnocarb exerts no immunostimulant action or any effect on the growth of experimental tumours.

Publication types

  • English Abstract

MeSH terms

  • Adjuvants, Immunologic*
  • Animals
  • Antineoplastic Agents*
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Hypersensitivity, Delayed / immunology
  • Lymphocyte Activation / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Neoplasms, Experimental / drug therapy
  • Oxadiazoles / immunology*
  • Psychotropic Drugs
  • Rabbits
  • Rosette Formation
  • Sydnones / immunology*
  • Time Factors

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Oxadiazoles
  • Psychotropic Drugs
  • Sydnones
  • sydnophen
  • sidnocarb