Synthesis and evaluation of substituted quinazolone derivatives for antibacterial, antifungal, and antiacetylcholinesterase activities

J Pharm Sci. 1980 Nov;69(11):1313-7. doi: 10.1002/jps.2600691120.


The synthesis of new 6-bromo- and 6,8-dibromo-2-[N-(2'-alkyl-1',3',4'-thiadizol-5'-yl)carbamoylmethylthio] -3-aryl/cyclohexyl-4-(3H)-quinazolones is described. The synthesis derivatives were screened for antibacterial, antifungal, and antiacetylcholinesterase activities in vitro. Most of the compounds exhibited significant biological activity. The relation between their biological activity and chemical structure was studied.

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemical synthesis
  • Anti-Infective Agents / pharmacology*
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / pharmacology*
  • Bacteria / drug effects
  • Cholinesterase Inhibitors*
  • Fungi / drug effects
  • Quinazolines / chemical synthesis
  • Quinazolines / pharmacology*
  • Structure-Activity Relationship


  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Cholinesterase Inhibitors
  • Quinazolines