Phenytoin-induced teratogenesis: a mouse model

Science. 1981 Jan 30;211(4481):483-4. doi: 10.1126/science.7455686.


Malformations associated with the fetal hydantoin syndrome have been reproduced in a mouse model. The occurrence of these defects was correlated with maternal serum concentrations, but not with maternal or fetal genotype or the presence of a seizure disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Epilepsy / drug therapy
  • Female
  • Mice
  • Mice, Neurologic Mutants / physiology
  • Phenytoin / adverse effects*
  • Teratogens*


  • Teratogens
  • Phenytoin