Pharmacokinetics and analgesic effect of ketamine in man

Br J Anaesth. 1981 Jan;53(1):27-30. doi: 10.1093/bja/53.1.27.


The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 microgram kg-1 and 250 microgram kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischaemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed rapidly (T 1/2 alpha = 17 min). The elimination half-life was 186 min.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesia*
  • Half-Life
  • Humans
  • Injections, Intravenous
  • Ketamine / administration & dosage
  • Ketamine / blood*
  • Ketamine / pharmacology
  • Kinetics
  • Male


  • Ketamine