Serial changes in renal haemodynamics during normal human pregnancy

Br J Obstet Gynaecol. 1981 Jan;88(1):1-9. doi: 10.1111/j.1471-0528.1981.tb00929.x.


Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were determined at constant intervals during and after the normal pregnancies in 25 healthy women. Compared with non-pregnant values, ERPF increased by 80 percent during early pregnancy but fell significantly from this new level during the third trimester. GFR, however, remained at a level 50 per cent above the non-pregnant throughout pregnancy. Filtration fraction (GFR/ERPF) was significantly reduced during early pregnancy but rose to a value equivalent to the non-pregnant during the third trimester. Comparable data of previous workers are re-interpreted.

MeSH terms

  • Adult
  • Female
  • Gestational Age
  • Glomerular Filtration Rate
  • Hemodynamics
  • Humans
  • Kidney / blood supply*
  • Pregnancy*
  • Regional Blood Flow