Thermostability and aliphatic index of globular proteins

J Biochem. 1980 Dec;88(6):1895-8.


A statistical analysis shows that the aliphatic index, which is defined as the relative volume of a protein occupied by aliphatic side chains (alanine, valine, isoleucine, and leucine), of proteins of thermophilic bacteria is significantly higher than that of ordinary proteins. The index may be regarded as a positive factor for the increase of thermostability of globular proteins.

Publication types

  • Comparative Study

MeSH terms

  • Alanine / analysis*
  • Bacterial Proteins / analysis*
  • Chemical Phenomena
  • Chemistry
  • Drug Stability
  • Geobacillus stearothermophilus / enzymology
  • Hot Temperature
  • Isoleucine / analysis*
  • Leucine / analysis*
  • Statistics as Topic
  • Valine / analysis*


  • Bacterial Proteins
  • Isoleucine
  • Leucine
  • Valine
  • Alanine