Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine

Mol Pharmacol. 1980 Nov;18(3):536-42.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaminophen / analogs & derivatives*
  • Acetaminophen / metabolism*
  • Animals
  • Ascorbic Acid / pharmacology
  • Benzoquinones*
  • Cysteine / pharmacology
  • Imines / metabolism*
  • In Vitro Techniques
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / metabolism
  • NADP / metabolism
  • Oxidation-Reduction
  • Rats

Substances

  • Benzoquinones
  • Imines
  • Acetaminophen
  • NADP
  • N-hydroxyacetaminophen
  • Mixed Function Oxygenases
  • N-acetyl-4-benzoquinoneimine
  • Cysteine
  • Ascorbic Acid