Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution

Nature. 1981 Jan 29;289(5796):366-73. doi: 10.1038/289366a0.


The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of alpha-helices extends 76 A from the membrane and a globular region of antiparallel beta-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 A distally and folding back to enter the membrane.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Carbohydrates / analysis
  • Glycoproteins* / biosynthesis
  • Hemagglutinins, Viral*
  • Hydrogen Bonding
  • Influenza A virus*
  • Macromolecular Substances
  • Membrane Proteins* / biosynthesis
  • Protein Conformation
  • Viral Proteins* / biosynthesis
  • X-Ray Diffraction


  • Carbohydrates
  • Glycoproteins
  • Hemagglutinins, Viral
  • Macromolecular Substances
  • Membrane Proteins
  • Viral Proteins