doi: 10.1016/0300-483x(80)90053-0.
Testicular atrophy induced by phthalic acid monoesters: effects of zinc and testosterone concentrations
- PMID: 7466832
- DOI: 10.1016/0300-483x(80)90053-0
Item in Clipboard
Testicular atrophy induced by phthalic acid monoesters: effects of zinc and testosterone concentrations
Toxicology.
1980.
Abstract
Induction of testicular atrophy by monoesters of phthalic acid were compared in male Wistar rats. Dietary administration of monobutyl (MBP), mono-iso-butyl (MIBP) and mono-2-ethylhexyl phthalate (MEHP) induced severe atrophy of the testes. Furthermore, high testosterone concentration in the testes was found in MBP- and MIBP-treated rats, whereas low zinc concentration was found in MBP-, MIBP- and MEHP-treated rats. On the other hand, in monooctyl phthalate (MOP)-treated rats, testosterone and zinc concentrations in the testes were not changed. These were similar to the results with their diesters.
Similar articles
-
Effects of phthalic acid monoesters on mouse testes.Toxicol Lett. 1980 Sep;6(4-5):239-42. doi: 10.1016/0378-4274(80)90126-5. Toxicol Lett. 1980. PMID: 7423552
-
Reversibility of testicular atrophy induced by Di(2-ethylhexyl) phthalate in rats.Environ Res. 1985 Feb;36(1):160-9. doi: 10.1016/0013-9351(85)90014-3. Environ Res. 1985. PMID: 3967638
-
Species differences in the testicular toxicity of phthalate esters.Toxicol Lett. 1982 Apr;11(1-2):141-7. doi: 10.1016/0378-4274(82)90119-9. Toxicol Lett. 1982. PMID: 7090005
-
Testicular effects of phthalate esters.Environ Health Perspect. 1982 Nov;45:77-84. doi: 10.1289/ehp.824577. Environ Health Perspect. 1982. PMID: 6754364 Free PMC article. Review.
-
Possible impact of phthalates on infant reproductive health.Int J Androl. 2006 Feb;29(1):172-80; discussion 181-5. doi: 10.1111/j.1365-2605.2005.00642.x. Int J Androl. 2006. PMID: 16466537 Review.
Cited by
-
Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data.Front Pharmacol. 2023 Feb 2;14:1111433. doi: 10.3389/fphar.2023.1111433. eCollection 2023. Front Pharmacol. 2023. PMID: 36865923 Free PMC article.
-
Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data.Front Pharmacol. 2021 Sep 2;12:692442. doi: 10.3389/fphar.2021.692442. eCollection 2021. Front Pharmacol. 2021. PMID: 34539393 Free PMC article.
-
Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl phthalate (DBP)-induced male reproductive toxicity.Reprod Toxicol. 2020 Sep;96:445-458. doi: 10.1016/j.reprotox.2019.06.009. Epub 2019 Jun 28. Reprod Toxicol. 2020. PMID: 31260805 Free PMC article. Review.
-
Hazards of diisobutyl phthalate (DIBP) exposure: A systematic review of animal toxicology studies.Environ Int. 2019 Apr;125:579-594. doi: 10.1016/j.envint.2018.09.038. Epub 2018 Dec 25. Environ Int. 2019. PMID: 30591249 Free PMC article.
-
Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.Int J Environ Res Public Health. 2017 Oct 24;14(10):1284. doi: 10.3390/ijerph14101284. Int J Environ Res Public Health. 2017. PMID: 29064414 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
