Biochemical genetics of glutathione-S-transferase in man

Am J Hum Genet. 1981 Jan;33(1):36-43.


Glutathione-S-transferases from liver and erythrocytes have been separated by starch gel electrophoresis and localized by a specific staining procedure. The data suggest that the most active glutathione-S-transferases in liver are the products of two autosomal loci, GST1 and GST2. Both these loci are polymorphic, and there is evidence that a common null allele exists at the GST1 locus. The glutathione-S-transferase expressed in erythrocytes is the product of a third locus, GST3, and is not polymorphic.

MeSH terms

  • Chromosome Mapping
  • Electrophoresis, Starch Gel
  • Erythrocytes / enzymology
  • Genes*
  • Glutathione Transferase / genetics*
  • Humans
  • Liver / enzymology
  • Polymorphism, Genetic


  • Glutathione Transferase