Glucocorticosteroid inhibition of intraocular proliferation after injury

Am J Ophthalmol. 1981 Feb;91(2):184-9. doi: 10.1016/0002-9394(81)90171-9.


Perforating injuries were produced in the posterior segment of rabbit eyes. We studied the inhibitory effect of a slowly water-soluble corticosteroid, dexamethasone alcohol, on fibroblast growth. The treated group received a single intravitreal injection of 1 mg of the corticosteroid. The eyes were observed for four weeks. Transvitreal proliferation was significantly decreased and wound healing was delayed as compared to a control group. Inhibition of intraocular proliferation by high doses of intravitreally injected corticosteroid may be useful in the treatment of eyes with penetrating and perforating injuries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dexamethasone / pharmacology
  • Dexamethasone / therapeutic use*
  • Eye Injuries / drug therapy*
  • Eye Injuries / pathology
  • Eye Injuries / physiopathology
  • Female
  • Fibroblasts / drug effects
  • Rabbits
  • Wound Healing / drug effects*


  • Dexamethasone