Inhalation of racemic epinephrine in children with asthma. Dose-response relation and comparison with salbutamol

Allergy. 1980 Oct;35(7):605-10. doi: 10.1111/j.1398-9995.1980.tb01811.x.


In this study the effects of nebulized racemic epinephrine (Micronephrine) were investigated in children with asthma. The drug was inhaled by a compressor nebulizer with a plastic mask. In the first part of the study it is shown that nebulized Micronephrine has a dose-dependent bronchodilatory effect. In the second part the effect is compared with that of nebulized salbutamol in 10 children (7-16 years of age) with bronchial asthma. The highest dose used in the dose-response trials (=0.9 mg Micronephrine/kg body-weight) was compared with 0.15 mg salbutamol/kg body-weight, which is the dose commonly used in Sweden. There was no significant difference between the drugs as regards increase of forced expiratory volume in 1 sec or duration of the increase. There was a small but significant increase in systolic blood pressure, measured 5 min after the inhalation of Micronephrine but no significant change in diastolic pressure or heart rate. Four children complained of temporary sore throat after the inhalation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Administration, Intranasal
  • Adolescent
  • Albuterol / administration & dosage*
  • Albuterol / adverse effects
  • Albuterol / therapeutic use
  • Asthma / drug therapy*
  • Child
  • Dose-Response Relationship, Drug
  • Epinephrine / administration & dosage*
  • Epinephrine / adverse effects
  • Epinephrine / therapeutic use
  • Forced Expiratory Volume
  • Humans
  • Racepinephrine*


  • Racepinephrine
  • Albuterol
  • Epinephrine