Abstract
Oral administration of CS-500, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, lowered the serum cholesterol level of both normal and WHHL-rabbits (the first example of heritable hyperlipidemic animals) at doses higher than 5 mg/kg/day. Phospholipids decreased concomitantly, whereas triglycerides did not in either normal or WHHL-rabbits.
MeSH terms
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Animals
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Body Weight
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Cholesterol / blood
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Disease Models, Animal*
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Dose-Response Relationship, Drug
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Female
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Food
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Hyperlipidemias / drug therapy
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Hyperlipidemias / genetics*
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Hypolipoproteinemias / etiology*
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Lovastatin* / analogs & derivatives*
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Male
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Naphthalenes / therapeutic use*
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Phospholipids / blood
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Rabbits
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Triglycerides / blood
Substances
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Naphthalenes
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Phospholipids
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Triglycerides
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mevastatin
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Cholesterol
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Lovastatin