Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia

Atherosclerosis. 1981 Jan-Feb;38(1-2):27-31. doi: 10.1016/0021-9150(81)90100-3.

Abstract

Oral administration of CS-500, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, lowered the serum cholesterol level of both normal and WHHL-rabbits (the first example of heritable hyperlipidemic animals) at doses higher than 5 mg/kg/day. Phospholipids decreased concomitantly, whereas triglycerides did not in either normal or WHHL-rabbits.

MeSH terms

  • Animals
  • Body Weight
  • Cholesterol / blood
  • Disease Models, Animal*
  • Dose-Response Relationship, Drug
  • Female
  • Food
  • Hyperlipidemias / drug therapy
  • Hyperlipidemias / genetics*
  • Hypolipoproteinemias / etiology*
  • Lovastatin* / analogs & derivatives*
  • Male
  • Naphthalenes / therapeutic use*
  • Phospholipids / blood
  • Rabbits
  • Triglycerides / blood

Substances

  • Naphthalenes
  • Phospholipids
  • Triglycerides
  • mevastatin
  • Cholesterol
  • Lovastatin