Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study

Br J Cancer. 1981 Feb;43(2):169-76. doi: 10.1038/bjc.1981.25.


A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin's disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate that exposure to phenoxy acids, chlorophenols, and organic solvents may be a causative factor in malignant lymphoma. Combined exposure of these chemicals seemed to increase the risk. Exposure to various other agents was not obviously different in cases and in controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,4,5-Trichlorophenoxyacetic Acid / adverse effects
  • 2-Methyl-4-chlorophenoxyacetic Acid / adverse effects
  • Adult
  • Aged
  • Benzene / adverse effects
  • Chlorophenols / adverse effects*
  • Glycolates / adverse effects*
  • Hodgkin Disease / chemically induced
  • Humans
  • Lymphoma / chemically induced*
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Solvents / adverse effects*
  • Styrenes / adverse effects
  • Trichloroethylene / adverse effects


  • Chlorophenols
  • Glycolates
  • Solvents
  • Styrenes
  • Trichloroethylene
  • 2,4,5-Trichlorophenoxyacetic Acid
  • 2-Methyl-4-chlorophenoxyacetic Acid
  • Benzene