Audiogenic seizures in rats: relation to noradrenergic neurons of the locus coeruleus

Acta Physiol Pol. 1978 Sep-Oct;29(5):409-12.

Abstract

Bilateral lesions involving the nucleus locus coeruleus produced a substantial decrease in the forebrain noradrenaline concentrations. Lesioned animals showed an increased susceptibility to audiogenic seizures. It is supposed that noradrenergic neurons, belonging to the locus coeruleus, play an inhibitory role in the seizure mechanism.

MeSH terms

  • Animals
  • Brain Chemistry
  • Dopamine / analysis
  • Locus Coeruleus / cytology
  • Locus Coeruleus / physiology*
  • Male
  • Norepinephrine / analysis
  • Rats
  • Seizures / physiopathology*
  • Serotonin / analysis
  • Sound

Substances

  • Serotonin
  • Dopamine
  • Norepinephrine