Acute lymphoblastic leukaemia in children: Classification and prognosis

Lancet. 1977 Dec;2(8052-8053):1307-9. doi: 10.1016/s0140-6736(77)90361-0.


Immunological (surface-marker) tests have been used to define four subgroups of acute lymphoblastic leukaemia (A.L.L.) in childhood: T-A.L.L., B-A.L.L., common-A.L.L., and null-A.L.L. A study of 94 children shows that the common-A.L.L. subgroup achieves a much longer duration of remission than T-A.L.L.; our findings also confirm the association of some clinical features with T-cell A.L.L. Within the common-A.L.L. subgroup, initial white-cell count correlates with prognosis.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • B-Lymphocytes
  • Cell Membrane / immunology
  • Child
  • Humans
  • Leukemia, Lymphoid / blood
  • Leukemia, Lymphoid / classification*
  • Leukemia, Lymphoid / mortality
  • Leukocyte Count
  • Prognosis
  • Remission, Spontaneous
  • T-Lymphocytes
  • Time Factors