Potentiation of the effects of chlorhexidine diacetate and cetylpyridinium chloride on mycobacteria by ethambutol

J Med Microbiol. 1995 Dec;43(6):458-60. doi: 10.1099/00222615-43-6-458.

Abstract

Ethambutol enhanced the effects of chlorhexidine diacetate and cetylpyridinium chloride against Mycobacterium avium, M. bovis BCG, M. fortuitum and M. phlei. The findings show that it is possible to increase the susceptibility of mycobacteria to agents that normally exhibit poor activity against these organisms because of their reduced cellular penetration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents, Local / pharmacology*
  • Antitubercular Agents / pharmacology*
  • Cetylpyridinium / pharmacology*
  • Chlorhexidine / pharmacology*
  • Colony Count, Microbial
  • Drug Combinations
  • Drug Interactions
  • Drug Synergism
  • Ethambutol / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium / drug effects*
  • Mycobacterium / physiology
  • Mycobacterium avium / drug effects
  • Mycobacterium bovis / drug effects
  • Nontuberculous Mycobacteria / drug effects

Substances

  • Anti-Infective Agents, Local
  • Antitubercular Agents
  • Drug Combinations
  • Ethambutol
  • Cetylpyridinium
  • Chlorhexidine