A dopamine D3 receptor agonist, 7-OH-DPAT, causes vomiting in the dog

Life Sci. 1995;57(21):PL347-50. doi: 10.1016/0024-3205(95)02186-m.

Abstract

R(+)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (R(+)-7-OH-DPAT), a selective dopamine D3 receptor agonist, (0.03-0.3 mg/kg, s.c.) dose-relatedly caused emesis, whereas S (-)-7-OH-DPAT at even 1 mg/kg did not induce emesis in dogs. Apomorphine (0.03-0.3 mg/kg, s.c.) or quinpirole (0.03-0.1 mg/kg, s.c.) also caused emesis in a dose-dependent manner. The potency of R(+)-7-OH-DPAT in inducing emesis was the same as that of apomorphine and quinpirole. On the other hand, SKF-38393 (1 and 3 mg/kg, s.c.), a selective D1 receptor agonist, failed to induce emesis in dogs. The emesis induced by R(+)-7-OH-DPAT (0.3 mg/kg, s.c.) was inhibited by S(-)-eticlopride (0.01-0.1 mg/kg, s.c.), a potent D2 and D3 receptor antagonist but not by SCH-23390 (1 mg/kg, s.c.), a selective D1 receptor antagonist or clozapine (1 mg/kg, s.c.), a D4 receptor antagonist. These results indicate that dopamine D3 receptors play an important role in the genesis of emesis in dogs.

MeSH terms

  • Animals
  • Dogs
  • Dopamine Agonists / toxicity*
  • Dopamine Antagonists / pharmacology
  • Dose-Response Relationship, Drug
  • Male
  • Receptors, Dopamine / drug effects*
  • Receptors, Dopamine D2*
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes / toxicity*
  • Vomiting / chemically induced*

Substances

  • Dopamine Agonists
  • Dopamine Antagonists
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes
  • 7-hydroxy-2-N,N-dipropylaminotetralin