Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance

Metabolism. 1995 Nov;44(11):1502-8. doi: 10.1016/0026-0495(95)90153-1.

Abstract

Aging is associated with an increased accumulation of abdominal fat, glucose intolerance, and insulin resistance. We tested the hypothesis that diet-induced weight loss would reduce the abdominal distribution of fat and improve glucose tolerance and insulin action in a group of obese middle-aged and older men with normal or impaired glucose tolerance (IGT). Oral glucose tolerance tests (OGTTs) were performed at baseline and after 9 months of diet-induced weight loss in 35 men (mean age, 60 +/- 8 years). Fifteen men of comparable age and degree of obesity who did not participate in the weight loss intervention served as controls. Subjects lost 9.0 +/- 2.0 kg (mean +/- SD) body weight (P < .001), resulting in a 19% reduction in percent body fat (30.0 +/- 4.0% to 24.0% +/- 4.0%, P < .001), an 8% reduction in waist circumference (104.0 +/- 7.0 to 96.0 +/- 7.0 cm, P < .001), and a 2% reduction in waist to hip ratio [WHR] (0.97 +/- 0.06 to 0.95 +/- 0.06, P < .01). Weight loss improved glucose tolerance: nine men with IGT at baseline reverted to normal glucose tolerance following the intervention. Glucose area during the OGTT was significantly reduced after weight loss (-22.0%, P < .001), while it increased in control subjects (+32%, P < .004). In multiple regression analysis, the improvement in glucose area following weight loss in these 35 men was attributed to the reduction in waist circumference (P < .01) and baseline glucose area (P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abdomen
  • Adipose Tissue / metabolism*
  • Aged
  • Aging / metabolism
  • Aging / physiology
  • Blood Glucose / analysis
  • Body Composition / physiology*
  • Body Constitution
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / physiopathology
  • Glucose / metabolism*
  • Glucose / pharmacology
  • Glucose Clamp Technique
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin / pharmacology*
  • Insulin Resistance / physiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Weight Loss / physiology*

Substances

  • Blood Glucose
  • Insulin
  • Glucose