Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors

Nature. 1995 Nov 30;378(6556):498-501. doi: 10.1038/378498a0.


There is little axonal growth after central nervous system (CNS) injury in adult mammals. The administration of antibodies (IN-1) to neutralize the myelin-associated neurite growth inhibitory proteins leads to long-distance regrowth of a proportion of CNS axons after injury. Our aim was: to determine if spinal cord lesion in adult rats, followed by treatment with antibodies to neurite growth inhibitors, can lead to regeneration and anatomical plasticity of other spinally projecting pathways; to determine if the anatomical projections persist at long survival intervals; and to determine whether this fibre growth is associated with recovery of function. We report here that brain stem-spinal as well as corticospinal axons undergo regeneration and anatomical plasticity after application of IN-1 antibodies. There is a recovery of specific reflex and locomotor functions after spinal cord injury in these adult rats. Removal of the sensorimotor cortex in IN-1-treated rats 2-3 months later abolished the recovered contact-placing responses, suggesting that the recovery was dependent upon the regrowth of these pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / physiology
  • Brain Stem / cytology
  • Cell Division
  • Growth Inhibitors / antagonists & inhibitors*
  • Growth Inhibitors / immunology
  • Locomotion
  • Nerve Regeneration*
  • Neural Pathways
  • Neuronal Plasticity
  • Rats
  • Rats, Inbred Lew
  • Reflex
  • Spinal Injuries / therapy*


  • Growth Inhibitors