Anticonvulsant effect of fluoxetine in humans

Neurology. 1995 Oct;45(10):1926-7. doi: 10.1212/wnl.45.10.1926.


We report an unblinded, open-label, add-on trial of fluoxetine, a selective serotonin reuptake inhibitor, in 17 patients with complex partial seizures with and without secondary generalization (mean follow-up duration, 14 +/- 1.1 months). Six patients showed complete disappearance of their daily seizures; in the others the seizure frequency was lowered by 30%. No patient reported side effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / therapeutic use*
  • Epilepsy / drug therapy*
  • Female
  • Fluoxetine / therapeutic use*
  • Humans
  • Male
  • Middle Aged


  • Anticonvulsants
  • Fluoxetine