Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response

Neurosci Lett. 1995 Aug 4;195(2):77-80. doi: 10.1016/0304-3940(95)11783-s.


D-20443 is an experimental antiepileptic drug. Its mechanism of antiepileptic action is unknown. We evaluated the anticonvulsant effectiveness of D-20443 against sound-induced seizures in genetically epilepsy-prone rats (GEPRs). This compound produced anticonvulsant effects against sound-induced seizures in moderate seizure GEPRs (GEPR-3s) at significantly lower doses than in severe seizure GEPRs (GEPR-9s). Based on these data and on the responses of GEPRs to other antiepileptic drugs, we predict that D-20443 will be a broad spectrum antiepileptic agent in humans. That is, we predict that D-20443 will suppress both tonic/clonic and absence seizures in humans.

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology*
  • Carbamates / pharmacology*
  • Dose-Response Relationship, Drug
  • Epilepsy / drug therapy*
  • Epilepsy / genetics
  • Female
  • Male
  • Phenylenediamines / pharmacology*
  • Rats
  • Rats, Inbred Strains


  • Anticonvulsants
  • Carbamates
  • Phenylenediamines
  • ezogabine