Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve

Neurosci Lett. 1995 Aug 4;195(2):93-6. doi: 10.1016/0304-3940(94)11789-l.


The conduction velocity of action potentials in nerve fibres is proportional to degree of myelination. Here we studied the influence of myelin ultrastructure on the compound action potential conduction velocity in optic nerves of the proteolipid protein (PLP)-deficient mouse model, which displays loose myelination in central fibres. We show that a myelin decompaction leads to a suboptimal conduction velocity. The significance of myelin ultrastructure for conduction of action potential in the optic nerve is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Age Factors
  • Animals
  • Central Nervous System / anatomy & histology
  • Electrophysiology
  • Mice
  • Myelin Sheath / physiology*
  • Myelin Sheath / ultrastructure
  • Neural Conduction / physiology*
  • Optic Nerve / physiology*
  • Optic Nerve / ultrastructure