Effect of local tranexamic acid gel in the treatment of epistaxis

ORL J Otorhinolaryngol Relat Spec. 1995 Jul-Aug;57(4):207-9. doi: 10.1159/000276741.


In patients with nosebleedings, the hemostatic effect of local application of tranexamic acid gel or placebo was compared in a randomized, double-blind, multicenter clinical trial with parallel groups. The times needed to arrest the initial bleeding were recorded, as well as any rebleedings within 10 days. The results showed no significant differences in any of the efficacy variables. Tranexamic acid was no better than placebo in the early treatment of nose bleedings, but the gel itself seemed to have a beneficial effect. The gel preparations were easy to insert into the nasal cavity and caused no discomfort to the patients.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Double-Blind Method
  • Epistaxis / drug therapy*
  • Female
  • Gels*
  • Humans
  • Male
  • Middle Aged
  • Severity of Illness Index
  • Time Factors
  • Tranexamic Acid / administration & dosage*
  • Tranexamic Acid / therapeutic use*
  • Treatment Outcome


  • Gels
  • Tranexamic Acid