Aerosolized furosemide in wheezy infants: a negative report

Pediatr Pulmonol. 1995 Jul;20(1):16-20. doi: 10.1002/ppul.1950200104.

Abstract

We investigated the effects of 10 mg aerosolized furosemide on clinical score in 28 acutely wheezing infants (Part A) and in a second group of 20 intermittently wheezing babies on airway resistance and functional residual capacity during a symptomfree period (Part B), using a double-blind, placebo-controlled design. In both parts of the study no therapeutic effects were observed during and following aerosol inhalation of 10 mg furosemide.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Inhalation
  • Aerosols
  • Airway Resistance / drug effects
  • Airway Resistance / physiology
  • Anti-Asthmatic Agents / administration & dosage*
  • Bronchiolitis / drug therapy*
  • Bronchiolitis / physiopathology
  • Double-Blind Method
  • Female
  • Functional Residual Capacity / drug effects
  • Functional Residual Capacity / physiology
  • Furosemide / administration & dosage*
  • Humans
  • Infant
  • Male
  • Respiratory Sounds / drug effects*
  • Respiratory Sounds / physiopathology
  • Treatment Failure

Substances

  • Aerosols
  • Anti-Asthmatic Agents
  • Furosemide