Thrombolytic-associated cholesterol emboli syndrome: case report and literature review

Pharmacotherapy. 1995 Jul-Aug;15(4):441-50.


Thrombolytics can cause cholesterol embolization syndrome (CES). This adverse effect has received less attention than other risks of thrombolytic therapy, such as systemic bleeding and hemorrhage, with only sporadic reports of CES in the literature. Risk factors have not been consistently identified and emphasized; therefore, occurrence of CES after thrombolysis remains difficult to predict, it results in substantial morbidity and mortality, and it lacks effective pharmacologic treatment. Heightened awareness of the disorder can aid in its correct identification and reporting.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Central Nervous System Diseases / etiology
  • Embolism, Cholesterol / etiology*
  • Female
  • Fibrinolytic Agents / adverse effects*
  • Humans
  • Kidney Diseases / etiology
  • Middle Aged
  • Retinal Diseases / etiology
  • Risk Factors
  • Skin Diseases / etiology
  • Syndrome
  • Thrombolytic Therapy / adverse effects


  • Fibrinolytic Agents