The regulation of stearoyl-CoA desaturase (SCD)

Prog Lipid Res. 1995;34(2):139-50. doi: 10.1016/0163-7827(94)00010-j.


The stearoyl-CoA desaturase gene family encodes stearoyl-CoA desaturase, the key enzyme involved in the biosynthesis of unsaturated fatty acids, as well as in the regulation of this process. Because of the important role that the SCD gene product plays in fat cell metabolism, future studies on SCD1 gene expression could provide new insights into the role of fatty acids in cellular regulation, metabolism, and gene expression both in normal and disease states. In addition, the SCD gene family can be used as a model to study mechanisms of cellular differentiation, tissue-specific gene expression, and dietary and hormonal regulation of gene expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carbohydrate Metabolism
  • Cell Differentiation / genetics*
  • Fatty Acids, Unsaturated / metabolism
  • Gene Expression Regulation, Enzymologic*
  • Insulin / metabolism
  • Liver / metabolism
  • Mice
  • Rats
  • Stearoyl-CoA Desaturase / genetics*


  • Fatty Acids, Unsaturated
  • Insulin
  • Stearoyl-CoA Desaturase