Spasmolytic flavonols from Artemisia abrotanum

Planta Med. 1995 Aug;61(4):370-1. doi: 10.1055/s-2006-958106.

Abstract

Four flavonols with spasmolytic activity have been isolated from a methanol extract of Artemisia abrotanum L. (Asteraceae), as the principles primarily responsible for the smooth muscle relaxing activity of this plant. The flavonols show a dose-dependent relaxing effect on the carbacholine-induced contraction of guinea-pig trachea, the EC50 values for compounds 1-3 are 20-30 mumol/l while compound 4 is less active.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / isolation & purification
  • Analgesics / pharmacology*
  • Animals
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Flavonols
  • Guinea Pigs
  • In Vitro Techniques
  • Muscle Relaxation / drug effects*
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology*
  • Parasympatholytics / isolation & purification
  • Parasympatholytics / pharmacology*
  • Plant Extracts*
  • Plants, Medicinal*
  • Structure-Activity Relationship
  • Trachea / drug effects
  • Trachea / physiology

Substances

  • Analgesics
  • Flavonoids
  • Flavonols
  • Parasympatholytics
  • Plant Extracts