Abstract
Four flavonols with spasmolytic activity have been isolated from a methanol extract of Artemisia abrotanum L. (Asteraceae), as the principles primarily responsible for the smooth muscle relaxing activity of this plant. The flavonols show a dose-dependent relaxing effect on the carbacholine-induced contraction of guinea-pig trachea, the EC50 values for compounds 1-3 are 20-30 mumol/l while compound 4 is less active.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / isolation & purification
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Analgesics / pharmacology*
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Animals
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Flavonols
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Guinea Pigs
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In Vitro Techniques
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Muscle Relaxation / drug effects*
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiology*
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Parasympatholytics / isolation & purification
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Parasympatholytics / pharmacology*
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Plant Extracts*
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Plants, Medicinal*
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Structure-Activity Relationship
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Trachea / drug effects
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Trachea / physiology
Substances
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Analgesics
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Flavonoids
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Flavonols
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Parasympatholytics
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Plant Extracts