Determination of strychnine and brucine by capillary zone electrophoresis

Y Y Zong; C T Che

doi:10.1055/s-2006-958136

Determination of strychnine and brucine by capillary zone electrophoresis

Planta Med. 1995 Oct;61(5):456-8. doi: 10.1055/s-2006-958136.

Authors

Y Y Zong¹, C T Che

Affiliation

¹ Department of Chemistry, Hong Kong University of Science and Technology, Kowloon.

PMID: 7480208
DOI: 10.1055/s-2006-958136

Abstract

A procedure for quantitative estimation of strychnine and brucine in the extracts of Strychnos nux-vomica seeds by capillary zone electrophoresis (CZE) was developed. The buffer solution used was 10mM phosphate buffer-MeOH (9:1), pH 2.5. The linear calibration range was 0.01-0.15 mg/ml. This method is useful for the qualitative and quantitative determination of strychnine and brucine in plant drug samples, as well as in human plasma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drugs, Chinese Herbal / chemistry*
Electrophoresis, Capillary / methods*
Feasibility Studies
Humans
Seeds / chemistry
Strychnine / analogs & derivatives*
Strychnine / analysis*
Strychnine / blood

Substances

Drugs, Chinese Herbal
brucine
Strychnine