A cytotoxic diacetylene from Dendropanax arboreus

Planta Med. 1995 Oct;61(5):470-1. doi: 10.1055/s-2006-958139.

Abstract

The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the acetylenic compound cis-1,9,16-heptadecatriene-4,6-diyne-3,8-diol.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkynes / chemistry
  • Alkynes / isolation & purification
  • Alkynes / pharmacology*
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cells, Cultured
  • Diynes
  • Drug Screening Assays, Antitumor
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology*
  • Humans
  • Liver / cytology
  • Liver / drug effects
  • Mice
  • Panax / chemistry*
  • Plants, Medicinal*
  • Rats
  • Tumor Cells, Cultured

Substances

  • Alkynes
  • Antineoplastic Agents, Phytogenic
  • Diynes
  • Fatty Alcohols
  • 1,9,16-heptadecatriene-4,6-diyne-3,8-diol