Abstract
The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the acetylenic compound cis-1,9,16-heptadecatriene-4,6-diyne-3,8-diol.
Publication types
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Letter
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkynes / chemistry
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Alkynes / isolation & purification
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Alkynes / pharmacology*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cells, Cultured
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Diynes
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Drug Screening Assays, Antitumor
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Fatty Alcohols / chemistry
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / pharmacology*
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Humans
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Liver / cytology
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Liver / drug effects
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Mice
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Panax / chemistry*
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Plants, Medicinal*
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Rats
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Tumor Cells, Cultured
Substances
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Alkynes
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Antineoplastic Agents, Phytogenic
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Diynes
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Fatty Alcohols
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1,9,16-heptadecatriene-4,6-diyne-3,8-diol