Uncommon pneumoconioses: CT and pathologic findings

Radiology. 1995 Nov;197(2):403-9. doi: 10.1148/radiology.197.2.7480684.

Abstract

Purpose: To correlate the computed tomographic (CT) features of pneumoconioses with histologic findings.

Materials and methods: Thin-section CT scans obtained in 48 patients with a history of occupational exposure to dust and radiographic changes suggestive of pneumoconiosis were retrospectively reviewed. Histologic samples were available in 22 cases.

Results: The most common CT features were as follows: in 21 arc welders, ill-defined micronodules concentrated in the centrilobular regions (n = 15); in 19 graphite workers, small nodular hyperattenuating areas (n = 17) (ill defined or well defined, corresponding to macular lesions along the walls of bronchioles and nodules, respectively), interlobular septal thickening (n = 11), and large hyperattenuating areas (n = 10); in aluminum pneumoconiosis, predominant reticular (n = 2), nodular (n = 2), and upper-lobe fibrosis (n = 2); and in hard-metal pneumoconiosis, multilobular ground-glass attenuation and consolidation with shrinkage (corresponding to marked intra-alveolar desquamation and multinucleated giant cells with mural mononuclear cell infiltrate).

Conclusion: Predominant findings are characteristic in each type of pneumoconiosis and are depicted at thin-section CT.

MeSH terms

  • Adult
  • Aged
  • Aluminum / adverse effects
  • Biopsy
  • Bronchi / pathology
  • Bronchography
  • Dust / adverse effects
  • Giant Cells / pathology
  • Graphite / adverse effects
  • Humans
  • Leukocytes, Mononuclear / pathology
  • Lung Diseases, Interstitial / diagnostic imaging
  • Lung Diseases, Interstitial / pathology
  • Male
  • Metallurgy
  • Metals / adverse effects
  • Middle Aged
  • Occupational Exposure
  • Pneumoconiosis / diagnostic imaging*
  • Pneumoconiosis / pathology*
  • Pulmonary Alveoli / diagnostic imaging
  • Pulmonary Alveoli / pathology
  • Pulmonary Emphysema / diagnostic imaging
  • Pulmonary Emphysema / pathology
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / pathology
  • Retrospective Studies
  • Tomography, X-Ray Computed*
  • Welding

Substances

  • Dust
  • Metals
  • Graphite
  • Aluminum