Biochemical and genetic dissection of mitotic chromosome condensation

Trends Biochem Sci. 1995 Sep;20(9):357-61. doi: 10.1016/s0968-0004(00)89076-3.


The molecular mechanisms responsible for mitotic chromosome condensation are unknown. Two independent approaches, biochemical studies in vertebrate cells and genetic analyses in yeasts, have converged recently, leading to the identification of a family of putative ATPases that play a fundamental role in this process. Further characterization of these proteins promises to uncover a highly dynamic aspect of mitotic chromosome architecture.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / physiology
  • Animals
  • Chromosomes / chemistry*
  • Chromosomes / genetics*
  • Interphase
  • Mitosis*
  • Nuclear Proteins / physiology


  • Nuclear Proteins
  • Adenosine Triphosphatases