GPI-anchor biosynthesis

Trends Biochem Sci. 1995 Sep;20(9):367-71. doi: 10.1016/s0968-0004(00)89078-7.


Many eukaryotic proteins bind to membranes using a glycosylphosphatidylinositol (GPI) anchor. GPI anchors are essential in yeasts and probably also in protozoa. Although mammalian cells can survive without GPI anchors, their deficiency in haemopoietic cells cause a haemolytic disease, paroxysmal nocturnal haemoglobinuria (PNH). Here, we discuss recent progress in our understanding of GPI-anchor biosynthesis that could lead to a better understanding of PNH and chemotherapeutic agents to treat protozoal and fungal infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carbohydrate Sequence
  • Glycosylphosphatidylinositols / biosynthesis*
  • Humans
  • Molecular Sequence Data


  • Glycosylphosphatidylinositols