What to do at an end: DNA double-strand-break repair

Trends Genet. 1995 Oct;11(10):388-92. doi: 10.1016/s0168-9525(00)89121-0.


Repairing chromosome breaks is essential to cell survival. A major lethal effect of ionizing radiation (IR) damage is the creation of double-strand DNA breaks. Recently, a number of mammalian cell mutants that are sensitive to IR damage have been described, revealing a unique repair pathway. The DNA-dependent protein kinase (DNA-PK) is necessary for double-strand-break repair and lymphoid V(D)J recombination. DNA-PK consists of three subunits: the Ku autoantigen heterodimer and a kinase (DNA-PKCS) that is deficient in mouse scid mutant cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • DNA Damage
  • DNA Repair / physiology*
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Mice
  • Mice, SCID
  • Protein-Serine-Threonine Kinases / physiology*


  • DNA-Binding Proteins
  • DNA-Activated Protein Kinase
  • Protein-Serine-Threonine Kinases