Flagellar assembly in two hundred and fifty easy-to-follow steps

Trends Genet. 1995 Oct;11(10):398-404. doi: 10.1016/s0168-9525(00)89123-4.


The eukaryotic flagellum is a complex biochemical machine that moves cells or moves materials over the surface of cells, such as in the mammalian esophagus, oviduct or in protozoa. It is composed of over 250 polypeptides that must be assembled into a number of different structures and each structure must be attached with an exact periodicity along the microtubules. Once the flagellum is assembled, each of the components must act in concert and in three dimensions to produce a complex waveform. This review provides an outline of the composition and function of the different structures found in the flagella of Chlamydomonas.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chlamydomonas reinhardtii / chemistry
  • Chlamydomonas reinhardtii / genetics
  • Chlamydomonas reinhardtii / physiology*
  • Dyneins / chemistry
  • Dyneins / genetics
  • Dyneins / physiology
  • Flagella / chemistry*
  • Flagella / genetics
  • Flagella / physiology
  • Microtubule Proteins / analysis*
  • Microtubule Proteins / chemistry
  • Microtubule Proteins / physiology
  • Microtubules / chemistry
  • Microtubules / physiology
  • Tubulin / chemistry
  • Tubulin / genetics
  • Tubulin / physiology


  • Microtubule Proteins
  • Tubulin
  • Dyneins