Retrograde signaling at GABAA-receptor synapses in the mammalian CNS

Trends Neurosci. 1995 Aug;18(8):333-40. doi: 10.1016/0166-2236(95)93923-l.


Recent studies have emphasized the role of signals that travel from a target cell, in a retrograde direction, to cells that synapse on the target and influence their output. While the focus of most research on this topic has been on long-lasting alterations at excitatory synapses, evidence that implicates retrograde transmission in the transient reduction of GABAA-receptor-mediated inhibition in hippocampus and cerebellum has begun to accumulate. Brief depolarizations of the postsynaptic principal cells lead to increases in the intracellular concentration of Ca2+, and a reduction in GABAA-receptor-mediated responses for 1-2 min. No concomitant reduction in postsynaptic GABAA-receptor responsiveness has been detected. Rather, release of GABA from inhibitory-interneuron terminals appears to be reduced. The properties of this 'depolarization-induced suppression of inhibition' might be appropriate for unique physiological roles.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System / physiology*
  • Humans
  • Receptors, GABA-A / physiology*
  • Signal Transduction / physiology*
  • Synapses / physiology*


  • Receptors, GABA-A