Oral and topical treatment of erectile dysfunction. Present and future

Urol Clin North Am. 1995 Nov;22(4):879-86.


A great deal of progress has been made in the pharmacological treatment of erectile dysfunction. At present, however, the most effective therapies require intracavernosal injections with a number of associated drawbacks. An increasing number of oral and transdermal agents have been introduced clinically or are at various phases in their development. It is evident that severe end-organ disease probably will not result in successful systemic therapy. Nevertheless, in men with intact or mildly dysfunctional erectile mechanisms, noninvasive treatments can offer some measure of success. Further study of individual and synergistic activity of available compounds is underway.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Adrenergic Antagonists / administration & dosage
  • Dopamine Agonists / administration & dosage
  • Erectile Dysfunction / drug therapy*
  • Hormones / administration & dosage
  • Humans
  • Male
  • Penile Erection / drug effects*
  • Serotonin Receptor Agonists / administration & dosage


  • Adrenergic Antagonists
  • Dopamine Agonists
  • Hormones
  • Serotonin Receptor Agonists