Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases

Vitam Horm. 1995;51:339-70. doi: 10.1016/s0083-6729(08)61044-4.

Abstract

Steroid hormone biosynthesis requires the concerted action of a related group of cytochrome P-450 steroid hydroxylases. In recent years considerable effort has been directed toward defining the molecular basis for the cell-selective expression of these genes and their transcriptional regulation by trophic hormones. The orphan nuclear receptor SF-1, acting through a conserved element found in the proximal promoter regions of all steroid hydroxylase genes, seems to be a major, but not exclusive, determinant of cell-selective gene expression. In contrast, the coordinate responses of the steroid hydroxylases to trophic hormones apparently involves an interplay of multiple proteins that collectively lead to a synchronous induction of gene expression. In some instances these interactions apparently involve transcription factors that also contribute to the cell-selective expression of these genes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclic AMP Response Element-Binding Protein
  • Cytochrome P-450 Enzyme System / genetics*
  • DNA-Binding Proteins
  • Fushi Tarazu Transcription Factors
  • Gene Expression Regulation*
  • Homeodomain Proteins
  • Humans
  • Organ Specificity
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Proto-Oncogene Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Steroid Hydroxylases / genetics*
  • Steroidogenic Factor 1
  • Steroids / biosynthesis
  • Transcription Factors
  • Transcription, Genetic*

Substances

  • Cyclic AMP Response Element-Binding Protein
  • DNA-Binding Proteins
  • Fushi Tarazu Transcription Factors
  • Homeodomain Proteins
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Proto-Oncogene Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Steroidogenic Factor 1
  • Steroids
  • Transcription Factors
  • pbx1 protein, human
  • Cytochrome P-450 Enzyme System
  • Steroid Hydroxylases