Risk factors for post-stroke depression

Acta Psychiatr Scand. 1995 Sep;92(3):193-8. doi: 10.1111/j.1600-0447.1995.tb09567.x.


An unselected cohort of 285 stroke patients, median age 69 years, were studied for correlation between potential risk factors and the 1-year incidence of post-stroke depression (PSD). The following factors correlated significantly with PSD: a history of previous stroke, a history of previous depression, female gender, living alone and social distress prestroke. Further, social inactivity, decrease in social activity, pathological crying and intellectual impairment at 1 month but not functional outcome correlated to PSD. A multivariate regression analysis showed that intellectual impairment explained 42% of variance of mood score. Major depression was unrelated to lesion location. We conclude that etiology to PSD is a complex mixture of prestroke personal and social factors, and stroke induced social, emotional and intellectual handicap.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living / psychology
  • Adaptation, Psychological
  • Aged
  • Cerebrovascular Disorders / diagnosis
  • Cerebrovascular Disorders / psychology*
  • Depressive Disorder / diagnosis
  • Depressive Disorder / psychology*
  • Female
  • Humans
  • Male
  • Neurocognitive Disorders / diagnosis
  • Neurocognitive Disorders / psychology*
  • Neuropsychological Tests
  • Personality Assessment
  • Risk Factors
  • Sick Role*
  • Social Environment