Effect of long-term angiotensin-converting enzyme inhibition on vascular function in patients with chronic congestive heart failure

Am J Cardiol. 1995 Nov 15;76(14):1079-82. doi: 10.1016/s0002-9149(99)80305-1.

Abstract

The present study demonstrates that peripheral vasodilatory capacity is impaired in patients with chronic congestive heart failure not treated with aspirin, but preserved in patients taking aspirin. This decreased peripheral vasodilatory capacity can be restored by chronic angiotensin-converting enzyme inhibition, indicating that locally acting cyclooxygenase-dependent factors contribute to peripheral vasoconstriction in chronic congestive heart failure.

MeSH terms

  • Adult
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Chronic Disease
  • Female
  • Heart Failure / drug therapy*
  • Heart Failure / physiopathology
  • Humans
  • Indoles / therapeutic use*
  • Male
  • Middle Aged
  • Perindopril
  • Radial Artery / drug effects
  • Radial Artery / physiopathology
  • Vascular Resistance / drug effects*
  • Vasodilation / drug effects*

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Indoles
  • Perindopril