Human immunodeficiency virus rather than hepatitis C virus infection is relevant to the development of an anti-cardiolipin antibody

Am J Hematol. 1995 Nov;50(3):220-2. doi: 10.1002/ajh.2830500312.


We have investigated whether or not a relationship exists between anti-cardiolipin antibody (aCL) positivity and human immunodeficiency virus type 1 (HIV) and/or hepatitis C virus (HCV), and we have attempted to clarify which virus has close association with the development of aCL. We found that aCL positivity in HIV-infected patients was significantly higher than in HCV-infected patients. Furthermore, HIV/HCV dual-infected patients exhibited a higher aCL positivity than patients infected by HCV alone. From these results, we conclude that HIV rather than HCV plays an important role in the development of aCL.

MeSH terms

  • Antibodies, Anticardiolipin / metabolism*
  • HIV Infections / immunology*
  • Hemophilia A / complications
  • Hepatitis C / immunology*
  • Humans


  • Antibodies, Anticardiolipin