Interleukin-10 in the vitreous of patients with primary intraocular lymphoma

Am J Ophthalmol. 1995 Nov;120(5):671-3. doi: 10.1016/s0002-9394(14)72217-2.


Purpose: To find an accurate and simple method to diagnose primary intraocular lymphoma.

Methods: We prospectively analyzed concentrations of interleukin-10, interleukin-1, interleukin-2, interleukin-4, and interleukin-6 in vitrectomy specimens from three patients with primary intraocular lymphoma and five patients with uveitis by enzyme-linked immunosorbent assay.

Results: Interleukin-10 in the vitreous was detected in patients with primary intraocular lymphoma. Interleukin-10 levels correlated with clinical activity and the number of malignant cells.

Conclusion: Concentrations of interleukin-10 in the vitreous may be a helpful clue to both clinicians and pathologists in diagnosing primary intraocular lymphoma.

MeSH terms

  • Enzyme-Linked Immunosorbent Assay
  • Eye Neoplasms / diagnosis*
  • Eye Neoplasms / surgery
  • Humans
  • Interleukin-10 / analysis*
  • Interleukins / analysis
  • Lymphoma, B-Cell / diagnosis*
  • Lymphoma, B-Cell / surgery
  • Prospective Studies
  • Uveitis / diagnosis
  • Uveitis / surgery
  • Vitrectomy
  • Vitreous Body / chemistry*


  • Interleukins
  • Interleukin-10