Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases

Biochem J. 1995 Nov 1;311 ( Pt 3)(Pt 3):717-21. doi: 10.1042/bj3110717.

Abstract

The cDNA and derived amino acid sequence of human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase have been determined with the aid of the GenBank Expressed Sequence Tag database. This enzyme possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. It is unrelated to the enzymes of diadenosine tetraphosphate catabolism found in prokaryotes and fungi.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Nucleotidyltransferases / analysis
  • Nucleotidyltransferases / chemistry
  • Nucleotidyltransferases / genetics*
  • Placenta / enzymology
  • Protein Structure, Secondary
  • Pyrophosphatases / genetics*
  • Sequence Homology, Amino Acid

Substances

  • DNA, Complementary
  • Nucleotidyltransferases
  • diadenosine 5,5'''-P(1),P(4)-tetraphosphate alpha,beta-phosphorylase
  • Pyrophosphatases

Associated data

  • GENBANK/D16581
  • GENBANK/L07263
  • GENBANK/L25276
  • GENBANK/L31408
  • GENBANK/U30313
  • GENBANK/Z18416
  • SWISSPROT/P08337
  • SWISSPROT/P24236
  • SWISSPROT/P32664