Reelin: a novel extracellular matrix protein involved in brain lamination

Bioessays. 1995 Oct;17(10):832-4. doi: 10.1002/bies.950171003.


Normal development of the nervous system is achieved through an elaborate program of guided neuronal migration and axonal growth. In the last few years, a flood of research has dissected the molecular bases of these phenomena, and several cell-surface and extracellular matrix molecules, which are implicated in neuronal and axonal targeting processes, have been recognized. Taking this knowledge a step further, a recent paper by Tom Curran's group reports the molecular cloning of the gene deleted in the autosomal recessive mouse mutation reeler, affecting cortical neuronal migration. This gene encodes reelin, a novel extracellular matrix protein.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules, Neuronal / genetics
  • Cell Movement
  • Cloning, Molecular
  • Extracellular Matrix Proteins / genetics*
  • Gene Deletion
  • Mice
  • Nerve Tissue Proteins / genetics*
  • Nervous System / embryology*
  • Reelin Protein
  • Serine Endopeptidases


  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Nerve Tissue Proteins
  • Reelin Protein
  • Reln protein, mouse
  • Serine Endopeptidases