Quantification of rheumatoid synovitis by magnetic resonance imaging

Arthritis Rheum. 1995 Nov;38(11):1610-7. doi: 10.1002/art.1780381113.


Objective: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI).

Methods: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded.

Results: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments.

Conclusion: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / diagnosis*
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Synovitis / complications
  • Synovitis / diagnosis*


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium DTPA