GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease

Nat Med. 1995 Oct;1(10):1062-6. doi: 10.1038/nm1095-1062.


The earliest event so far known that occurs in the brain affected with Alzheimer's disease (AD) is the deposition and fibril formation of amyloid beta-protein (A beta). A beta is cleaved from a glycosylated membrane protein, called beta-amyloid protein precursor, and normally secreted into the extracellular space. Here we report on the presence of membrane-bound A beta that tightly binds GM1 ganglioside. This suggests that this novel A beta species, rather than secreted A beta, may act as a 'seed' for amyloid and further that intracellular abnormalities in the membrane recycling already exist at the stage of amyloidogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aging
  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / metabolism
  • Cerebral Cortex / metabolism*
  • Down Syndrome / metabolism
  • G(M1) Ganglioside / metabolism*
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Middle Aged
  • Neurofibrillary Tangles / metabolism
  • Peptide Fragments / metabolism


  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Membrane Glycoproteins
  • Peptide Fragments
  • amyloid beta-protein (1-42)
  • amyloid beta-protein (17-42)
  • G(M1) Ganglioside