Similar serological response to conventional therapy for syphilis among HIV-positive and HIV-negative women

Genitourin Med. 1995 Oct;71(5):275-9. doi: 10.1136/sti.71.5.275.


Objectives: To compare characteristics of syphilis serological reactivity in HIV positive (+) and HIV negative (-) female sex workers, as well as the serological response to therapy after treatment with intramuscular benzathine penicillin, 2.4 million U weekly, for three consecutive weeks.

Methods: Rapid plasma reagin (RPR) and Treponema pallidum haemagglutination assay (TPHA) results of 72 HIV-positive and 121 HIV-negative women reactive in both tests were assessed. The response to therapy was prospectively monitored with quantitative RPR serology in 47 HIV-positive and 73 HIV-negative patients. Cumulative probabilities of becoming nonreactive by RPR were compared at six months, one and two years after therapy.

Results: At enrolment, the geometric mean titres of RPR and TPHA were lower in HIV-positive patients (RPR, 1:2.6) than in HIV-negative patients (RPR, 1:3.8; p < 0.01). The evolution over time of RPR titres was similar among HIV-positive patients as compared to HIV-negative patients. Among patients with an initial RPR titre of < 1:8, 53% of HIV-positive and 44% of HIV-negative patients became RPR negative two years after therapy. Among patients with an RPR titre of 1:8 or greater at enrolment, 83% of HIV-positive and 90% of HIV-negative patients had reached at least a fourfold decline of RPR titres two years after therapy.

Conclusions: Syphilis serology findings (both RPR and TPHA) may be altered in the presence of HIV infection, but the serological response to therapy was similar in HIV-positive and HIV-negative patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Female
  • HIV Seronegativity*
  • HIV Seropositivity / complications*
  • Hemagglutination Tests
  • Humans
  • Penicillin G Benzathine / therapeutic use
  • Penicillins / therapeutic use
  • Prospective Studies
  • Reagins / blood
  • Syphilis / complications
  • Syphilis / drug therapy*
  • Syphilis / immunology*
  • Treponema pallidum / immunology


  • Penicillins
  • Reagins
  • Penicillin G Benzathine