Transcutaneous oxygen levels in retinopathy of prematurity

Lancet. 1995 Dec 2;346(8988):1464-5. doi: 10.1016/s0140-6736(95)92475-2.


Retinopathy of prematurity (ROP) is a potentially blinding disease of preterm infants. 21 days of computer-recorded transcutaneous oxygen (TcPO2) data were compared in 31 infants with stage 3 or greater ROP and 38 infants with no ROP or stage 1 or 2. In a multiple logistic regression adjusted for significant perinatal factors (birthweight, gestation, and intraventricular haemorrhage), babies with stage 3 or higher ROP showed an increased variability of TcPO2 in week 1 (p < 0.01) and 2 (p = 0.012) but not week 3. Variability of TcPO2 in the first 2 weeks of life is a significant predictor of severe ROP.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Gas Monitoring, Transcutaneous*
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature / blood*
  • Logistic Models
  • Male
  • Predictive Value of Tests
  • Retinopathy of Prematurity / blood*
  • Retinopathy of Prematurity / classification
  • Retinopathy of Prematurity / etiology