Lycorine alkaloids from Hymenocallis littoralis

L Z Lin; S F Hu; H B Chai; T Pengsuparp; J M Pezzuto; G A Cordell; N Ruangrungsi

doi:10.1016/0031-9422(95)00372-e

Lycorine alkaloids from Hymenocallis littoralis

Phytochemistry. 1995 Nov;40(4):1295-8. doi: 10.1016/0031-9422(95)00372-e.

Authors

L Z Lin¹, S F Hu, H B Chai, T Pengsuparp, J M Pezzuto, G A Cordell, N Ruangrungsi

Affiliation

¹ Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.

PMID: 7492374
DOI: 10.1016/0031-9422(95)00372-e

Abstract

From Hymenocallis littoralis, one new alkaloid, named littoraline, together with 13 known lycorine alkaloids and one lignan, were isolated. The structure and NMR assignments of this new alkaloid were determined by 1D and 2D NMR techniques. Littoraline showed inhibitory activity of HIV reverse transcriptase, and lycorine and haemanthamine showed potent in vitro cytotoxicity.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
HIV Reverse Transcriptase
HIV-1 / enzymology
Humans
Magnetic Resonance Spectroscopy
RNA-Directed DNA Polymerase / metabolism
Reverse Transcriptase Inhibitors / chemistry
Reverse Transcriptase Inhibitors / isolation & purification*
Reverse Transcriptase Inhibitors / pharmacology
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Tumor Cells, Cultured

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Reverse Transcriptase Inhibitors
HIV Reverse Transcriptase
RNA-Directed DNA Polymerase