t(8;21) breakpoints are clustered between alternatively spliced exons of MTG8

Clin Sci (Lond). 1995 Sep;89(3):215-8. doi: 10.1042/cs0890215.

Abstract

1. The (8;21) translocation, which is consistently associated with a subgroup of acute myeloid leukaemia, involves two loci: runt on chromosome 21 and MTG8 on chromosome 8. 2. Breakpoints in runt fall within a single intron that is located immediately downstream of a phylogenetically conserved DNA-binding domain (the 'runt box'). 3. We now show that most breakpoints on chromosome 8 fall within a region between two alternative 5' MTG8 exons. Thus, we predict that chimaeric genes on both the derivative(8) and the derivative(21) chromosomes have the potential to be transcriptionally active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Blotting, Southern
  • Chromosomes, Human, Pair 21 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • DNA-Binding Proteins / genetics
  • Drosophila Proteins
  • Exons / genetics*
  • Gene Expression Regulation, Leukemic / genetics*
  • Humans
  • Introns / genetics
  • Leukemia, Myeloid / genetics*
  • Nuclear Proteins
  • Proto-Oncogene Proteins*
  • RUNX1 Translocation Partner 1 Protein
  • Transcription Factors / genetics
  • Translocation, Genetic / genetics*

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • RUNX1 Translocation Partner 1 Protein
  • RUNX1T1 protein, human
  • Transcription Factors
  • run protein, Drosophila